There is now a rapidly expanding population of interlinked developmental biology databases on the World Wide Web that can be readily accessed from a desk‐top PC using programs such as Netscape or Mosaic. These databases cover popular organisms (Arabidopsis, Caenorhabditis, Drosophila, zebrafish, mouse, etc.) and include gene and protein sequences, lists of mutants, information on resources and techniques, and teaching aids. More complex are databases relating domains of gene expression to embryonic anatomy and these range from existing text‐based systems for (...) specific organs such as kidney, to a massive project under development, that will cover gene expression during the whole of mouse embryogenesis. In this brief article, we review selected examples of databases currently available, look forward to what will be available soon, and explain how to gain access to the World Wide Web. (shrink)

The authors discuss some of the conceptual issues that must be considered in using and understanding psychiatric classification. DSM-IV is a practical and common sense nosology of psychiatric disorders that is intended to improve communication in clinical practice and in research studies. DSM-IV has no philosophic pretensions but does raise many philosphical questions. This paper describes the development of DSM-IV and the way in which it addresses a number of philosophic issues: nominalism vs. realism, epistemology in science, the mind/body dichotomy, (...) the definition of mental disorders, and dimensional vs. categorical classification. (shrink)

post hos elefantorum fulgentium formidandam speciem et truculentos hiatus uix mentes pauidae perferebant; ad quorum stridorem odoremque et insuetum aspectum magis equi terrebantur. COKNELISSEN, Mnemosyne, xiv, 280, comments: ‘Non intellego fulgentium. Minime audiendus est Wagnerus, qui fulgentes elephantes dictos esse contendit ob cutem glabram. Corrigendum puto ingentium. Porro non satis intellego quomodo hiatus elefantorum militibus pauorem incutere potuerit. Wagnerus, qui omnia con-coquere solet, interpretatur proboscidas. Nescio an scripserit A. barritus.’.

As a concept, affordance is integral to scholarly analysis across multiple fields—including media studies, science and technology studies, communication studies, ecological psychology, and design studies among others. Critics, however, rightly point to the following shortcomings: definitional confusion, a false binary in which artifacts either afford or do not, and failure to account for diverse subject-artifact relations. Addressing these critiques, this article demarcates the mechanisms of affordance—as artifacts request, demand, allow, encourage, discourage, and refuse—which take shape through interrelated conditions: perception, dexterity, (...) and cultural and institutional legitimacy. Together, the mechanisms and conditions constitute a dynamic and structurally situated model that addresses how artifacts afford, for whom and under what circumstances. (shrink)

post hos elefantorum fulgentium formidandam speciem et truculentos hiatus uix mentes pauidae perferebant; ad quorum stridorem odoremque et insuetum aspectum magis equi terrebantur. COKNELISSEN, Mnemosyne, xiv , 280, comments: ‘Non intellego fulgentium. Minime audiendus est Wagnerus, qui fulgentes elephantes dictos esse contendit ob cutem glabram. Corrigendum puto ingentium. Porro non satis intellego quomodo hiatus elefantorum militibus pauorem incutere potuerit. Wagnerus, qui omnia con-coquere solet, interpretatur proboscidas. Nescio an scripserit A. barritus.’.

Structured interviews were held with 149 registered nurses in seven countries in America, Asia, Australia and Europe concerning the feeding of severely demented patients who do not accept food. The most common reasons for nurses being willing to change their decision to feed or not to feed were an order from the medical head, a request from the patient's husband and/or the staff meeting. There was a connection between the willingness to feed and the ranking of ethical principles. Nurses who (...) were most prone to feed the patient most often gave a high rank to the ethical principle of sanctity of life, while those who primarily chose not to feed the patient gave a high rank to the ethical principle of autonomy. All nurses stressed the ethical principle of beneficence. Des interviews structurés ont eu lieu avec 149 infirmiers/ères dans sept pays en Amérique, Asie, Australie et Europe concernant l'alimentation des malades gravement dément qui refusent de manger. La raison la plus générale pour des infirmiers/ères d'être prêt à changer leures décisions de donner à manger ou non sont: un ordre du médecin, la demande du mari de la malade ou de la réunion du personnel. Il y avait un lien entre la volonté de nourir et le rang des principes éthiques. Les infirmiers/ères les plus enclins de nourir la malade le plus souvent donnaient un rang supérieur au principe éthique de la sainteté de vie, pendant que ceux et celles qui choisissaient de ne pas nourrir la malade donnaient un rang supérieur au principe éthique de l'autonomie. Tous insistaient sur l'importance du principe éthique de la bienfaisance. Konstruktive Interviews wurden mit 149 ausgebildeten Krankenschwestern und Pfleger in sieben Ländern in Amerika, Asien, Australien und Europa gehalten über die Ernährung von schwer von Dementia praecox leidenden Patienten, die das Essen verweigern. Die gewöhnlichsten Gründe des Pflegepersonals für die Bereitwilligkeit, ihre Entscheidung, zu ernähren oder nicht, zu ändern, waren Anordnungen vom medizinischen Chef, Anfragen vom Ehemann der Patientin und/oder einer Personalsitzung. Es bestand ein Zusammenhang zwischen der Bereitwilligkeit zur Ernährung und dem Rang der ethischen Prinzipien. Die Pflegenden, die sich am meisten neigten, die Patientin zu ernähren, gaben dem ethischen Prinzip der Heiligkeit des Lebens einen hohen Rang, während die, die meistens vorzogen, die Patientin nicht zu ernähren, gaben dem ethischen Prinzip der Autonomie einen hohen Rang. Alle Pflegenden legten grossen Wert auf das ethische Prinzip der Wohltätigkeit. (shrink)

Thematically organized around the major concerns of Basil Bernstein's work as a sociologist, this book includes chapters from some of the leading sociologists and educational scholars. Each section attempts to provide a critical evaluation of Bernstein's work, framed within four interrelated contexts: his sociological theory, sociology of language and code theory, sociology of education and social reproduction, and the influence of his sociology on educational research. In a separate section, Bernstein himself responds to the earlier chapters. The book examines Bernstein's (...) sociology of schools in relation to his general sociological theory and in doing so demonstrates that sociology is an essential lens for understanding the structure and processes of schooling. It also provides a critical evaluation of the strengths and weaknesses of Bernstein's work, as well as a correction to current work in education, which eschews theory in favor of practicality. (shrink)

Cet article présente mes réflexions en leur état au début de l’année 2020 quant à la situation de la méthodologie économique et de la philosophie de l’économie (ou philosophie économique), après quinze années passées à la co-direction (avec Wade Hands) du Journal of Economic Methodology. J’y constate les changements des méta-champs de recherche que sont la méthodologie et la philosophie de l’économie, depuis leur surgissement comme sous-domaines au sein des sciences économiques durant les années 1980. En usant d’une analyse qui (...) prend en considération l’évolution technologique, j’y distingue deux scenarii envisageables pour l’avenir du champ, en rapport aux facteurs de l’environnement l’impactant, et quant à l’influence de la spécialisation croissante de la recherche, à la fois sur ce champ même et sur les sciences économiques ; j’élabore enfin une argumentation transdisciplinaire touchant son évolution future vers la diversité et la pluralité dans la recherche académique. (shrink)

The pituitary hormone prolactin (PRL) is best known for its role in the regulation of lactation. Recent evidence furthermore indicates PRL is required for normal reproduction in rodents. Here, we report on the insertion of two transposon-like DNA sequences in the human prolactin gene, which together function as an alternative promoter directing extrapituitary PRL expression. Indeed, the transposable elements contain transcription factor binding sites that have been shown to mediate PRL transcription in human uterine decidualised endometrial cells and lymphocytes. We (...) hypothesize that the transposon insertion event has resulted in divergent (pituitary versus extrapituitary) expression of prolactin in primates, and in differential actions of pituitary versus extrapituitary prolactin in lactation versus pregnancy respectively. Importantly, the TE insertion might provide a context for some of the conflicting results obtained in studies of PRL function in mice and man. (shrink)

In his paper ‘Scmantic Theory and Tacit Knowlcdgc’, Gareth Evans uscs a familiar kind of cxamplc in ordcr to render vivid his account of tacit knowledge. We arc to consider a finite language, with just one hundrcd scntcnccs. Each scntcncc is made up of a subjcct (a name) and a prcdicatc. The names are ‘a’, ‘b’, . . ., T. The prcdicatcs arc ‘F’, ‘G’, . . ., ‘O’. Thc scntcnccs have meanings which dcpcnd in a systematic way upon their (...) construction. Thus, all scntcnccs containing ‘a’ mean something about john; all scntcnccs containing ‘b’ mean something about Harry; all scntcnccs containing ‘F’ mean something about being bald; all scntcnccs containing ‘G’ mean something about being happy; and so 011. For this vcry simple language L, wc arc to consider various semantic theories. We could consider thcorics whosc dclivcranccs about wholc scntcnccs are of.. (shrink)

J’évalue de manière critique un certain nombre de thèses concernant la façon dont l’intention peut compléter ou supplanter la convention dans une théorie de l’interprétation. Je soutiens que la signification de l’énonciation ne peut être identifiée aux intentions du locuteur, qu’elles soient réelles ou attribuées. Ou bien l’identification de la signification de l’énonciation aux intentions réelles ne réussit pas à attribuer un rôle déterminant véritable à ces intentions, ou bien elle échoue à rendre compte de la manière dont ces intentions (...) peuvent déterminer la signification de l’énonciation. L’identification de la signification de l’énonciation aux intentions attribuées suppose implicitement : a) que la signification attribuée au locuteur ne détermine pas réellement la signification de l’énonciation ; b) qu’elle n’est pas en mesure de rendre compte des contextes « davidsoniens » dans lesquels un locuteur réalise ses intentions sémantiques par des moyens non conventionnels. Je mets en avant « l’intentionnalisme interprétatif », qui accorde un rôle déterminant à la « saisie » tout en respectant l’idée anti-conventionnaliste selon laquelle les significations de l’énonciation ne peuvent être attribuées qu’à ce que l’on peut supposer être les véhicules d’intentions sémantiques. Ce point de vue permet aussi de fonder une distinction entre l’interprétation dans les arts et l’interprétation dans des contextes conversationnels ordinaires.I critically assess a range of proposals as to how intention supplements or supplants convention in a theory of interpretation. Utterance meaning, I argue, cannot be identified with utterer’s intentions, whether actual or ascribed. Identifying utterance meaning with actual intentions either fails to ascribe a genuine determining role to such intentions, or lacks an account of how such intentions are able to render utterance meaning determinate. Identifying utterance meaning with ascribed intentions either involves the tacit admission that ascribed utterer’s meaning is not the real determinant of utterance meaning, or is unable to account for “Davidsonian” contexts in which a speaker realizes her semantic intentions through unconventional means. I propose an alternative account —“interpretive intentionalism”— that accords a determining role to “uptake” while respecting the anti-conventionalist observation that utterance meanings are only ascribed to presumed vehicles of semantic intentions, and that also grounds a principled distinction between interpretation in the arts and interpretation in ordinary conversational contexts. (shrink)

Sūkṣmāgama: Volume III, Chapters 54 to 85. Critical Edition. By S. Sambandhaśivācarya, B. Dagens, M.-L. Barazer-Billoret, and T. Ganesan with the collaboration of J.-M. Creisméas. Collection Indologie, vol. 114.3. Pondichéry: institut FranCçais de Pondichéry, 2018. Pp. cxcviii + 348.

Introduction: Experiential deconstructive inquiry -- Foundational philosophies and spiritual methods -- Non-duality in Advaita Vedanta and Zen Buddhism -- Ontological differences and non-duality -- Meditative inquiry, questioning, and dialoguing as a means to spiritual insight -- The undoing or deconstruction of dualistic conceptions -- Advaita Vedanta : philosophical foundations and deconstructive strategies -- Sources of the tradition -- Upaniads that art thou (Tat Tvam Asi) -- Gauapda (c.7th century) : no bondage, no liberation -- Aakara (c.7th-8th century) : there is (...) no apprehender different from this apprehension to apprehend it -- Modern and contemporary masters -- Ramana Maharshi (1879-1950) : who am I? -- H.W.L Poonja (1910-1997) : you have to do nothing to be who you are! -- Gangaji (b. 1942) : you are that! -- Advaita Vedanta summary : nothing ever happens -- Zen Buddhism : philosophical foundations and deconstructive strategies -- Sources of the tradition -- The Lakvatra Sutra and the Vajracchedik Prajñpramit Sutra all things ... are not independent of each other and not two -- Ngrjuna (c.113-213) : Sasra is Nirva -- Eihei Dgen (1200-1253) : if I am already enlightened, why must I practice -- Contemporary masters -- Ekai Korematsu (b. 1948) : return to the spine -- Hgen Yamahata (b. 1935) : why not now -- Zen Buddhism summary : neither being nor non-being is to be taken hold of -- Deconstructive techniques and dynamics of experiential undoing -- Deconstructive techniques common to both traditions -- The teacher-student dynamic -- Key deconstructive techniques -- Unfindability analysis -- Bringing everything back to the here and now -- Paradoxical problems -- Negation -- Dynamics of experiential undoing -- Non-dual experiential space -- Experiential mapping : practitioners in the space -- Experiential undoing in Advaita Vedanta -- Experiential undoing in Zen Buddhism -- Conclusion: Deconstruction of reified awareness. (shrink)

Does the recent success of Podemos and Syriza herald a new era of inclusive, egalitarian left populism? Because leaders of both parties are former students of Ernesto Laclau and cite his account of populism as guiding their political practice, this essay considers whether his theory supports hope for a new kind of populism. For Laclau, the essence of populism is an “empty signifier” that provides a means by which anyone can identify with the people as a whole. However, the concept (...) of the empty signifier is not as neutral as he assumes. As I show by analyzing the role of race in his theory, some subjects are constituted in a way that prevents their unmediated identification with the people. Consequently, Laclau’s view should be read as symptomatic of the problems with populist logic if its adherents are to avoid reproducing its exclusions and practice a more inclusive politics. (shrink)